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Today's date is Saturday, September 19, 2020
School of Molecular Sciences
 November 2012
Monday 26
12:00 - SEMINAR - LIWA Medical Research Seminar Series: : W/Prof John Newnham presents "Improving lung health by preventing prematurity" Website | More Information
LIWA invites you to a free seminar on: "Improving lung health by preventing prematurity" by W/Prof John Newnham, Head of School, School of Women's and Infants' Health, University of Western Australia. A light lunch will be served from 12.00pm with a 12.30pm – 1.30pm presentation.
Tuesday 27
9:00 - COURSE - R Basics : An introduction to the statistical package R Website | More Information
This course will take you through the basics you need to do statistical analyses in R, a powerful freeware statistical package.

The course will cover basic statistics such as t-tests, regression and ANOVA as well as producing high quality graphics.

The course is hosted by the Centre for Applied Statistics and we offer discounted rate fees to UWA Graduate Research Students.

Fee information is available on our website https://www.cas.maths.uwa.edu.au/courses. Please register online.

13:00 - SEMINAR - Respiratory load-induced cardiorespiratory failure : School of Anatomy, Physiology & Human Biology Seminar Series More Information
The Seminar: Respiratory loads have long been used to stress the respiratory muscles. When these loads cause failure, however, this has been attributed to inadequate pressure generation by the respiratory muscles, especially the diaphragm. Recently, we discovered that in a rat model of load-induced failure, inspiratory drive to the diaphragm was still elevated at the time of failure, indicating that the origin of failure was not central. However, blood pressure decreased and we observed that cardiac troponin, a marker specific for myocardial necrosis, was present. Troponin was released regardless of the type of respiratory load (inspiratory resistive, repeated inspiratory occlusions, and expiratory threshold). Thus, respiratory loads, by causing arterial hypoxemia, reduce O2 delivery to the heart and respiratory muscles. Inadequate O2 delivery, in the face of increased O2 demands, leads therefore to cardiorespiratory, not respiratory, failure. These results may be relevant to acute exacerbations of respiratory diseases, particularly when supplementary O2 is not available.

The Speaker: Prof Iscoe completed his undergraduate and Doctoral studies at McGill University and his post-doc at Albert Einstein College of Medicine. He now holds a cross-appointment with the Department of Biomedical and Molecular Sciences and Department of Medicine at Queen’s University. Prof Iscoe is a respiratory physiologist with a research interests in the control of the diaphragm; skeletal muscle fatigue and injury; cardiorespiratory failure; treatment of carbon monoxide poisoning; and hypercoagulability in obstructive sleep apnoea.
Thursday 29
9:00 - COURSE - Design and Analysis of Experiments : A Statistics Short Course using R Website | More Information
The course is designed for people with knowledge of basic statistics who want to learn more about designing and analysing experiments.

It will cover material ranging from a review of simple one-way ANOVA, to more complex designs and analyses including crossed and nested factors with fixed and random effects.

The course is hosted by the Centre for Applied Statistics and we offer discounted rate fees to UWA Graduate Research Students.

Fee information is available on our website https://www.cas.maths.uwa.edu.au/courses. Please register online.

 December 2012
Tuesday 04
9:00 - COURSE - Introduction to Structural Equation Modelling : A Short Course using AMOS and Mplus Website | More Information
SEM is used widely by researchers to test complex relationships among observed (measured) and latent (unobserved) variables. This course will introduce you to SEM and also covers issues relating to model specification, identification and estimation, assessing model fit (goodness-of-fit criteria), and dealing with problem data.

The course is hosted by the Centre for Applied Statistics and we offer discounted rate fees to UWA Graduate Research Students.

Fee information is available on our website https://www.cas.maths.uwa.edu.au/courses. Please register online.
Monday 10
9:00 - COURSE - Applied structural equation models : A Short Course using Mplus Website | More Information
The course is designed as a comprehensive coverage of applied SEM techniques using the Mplus statistical software package. Mplus offers a general modelling framework that allows both the modelling of cross-sectional and longitudinal data using observed variables that are a combination of continuous and categorical variables.

The course is hosted by the Centre for Applied Statistics and we offer discounted rate fees to UWA Graduate Research Students.

Fee information is available on our website https://www.cas.maths.uwa.edu.au/courses. Please register online.
Wednesday 12
13:00 - CONFERENCE - Occupational and Environmental Risk Assessment Half Day Conference : Perth Epidemiology Group brings to you the half day conference: Occupational and Environmental Risk Assessment Website | More Information
*Advanced methods in exposure assessment and epidemiology *Methods for combining exposure assessments and epidemiological models for use in risk assessment and risk prediction *Use of molecular markers in the identification of occupational and environmental risk factors *Heat stress and acclimatisation of workers, development of a biomarker of acclimatisation status *Risk assessment in environmental health decision making *Lessons learned from the Western Australian experience of mesothelioma
Thursday 13
16:00 - SEMINAR - CMCA Seminar Series - 13 December @ 4PM: "Non-medical applications of magnetic resonance imaging (MRI)" by Michael Johns Website | More Information
This presentation will consider the use of MRI techniques to explore some of the following topics: Flow in porous media (reactors and rock cores), flow in rheometers, fouling of desalination membranes, crystallisation/freezing processes and moisture adsorption by foodstuffs. It will conclude with an overview of robust and mobile MRI (and related technique) capabilities that have been established in the School of Mechanical and Chemical Engineering at UWA
Wednesday 19
13:00 - SEMINAR - How multisensory neurons in the auditory brainstem contribute to tinnitus : School of Anatomy, Physiology & Human Biology Seminar Series More Information
The Speaker:

Professor Susan Shore from the Department of Otolaryngology, University of Michigan has been working in the field of Neuroanatomy and Neurophysiology of the auditory system for more than two decades. Much of her work has focused on the role of neural connections from other parts of the brain to the cochlear nucleus. A strong emphasis has been on two major projection systems: the somatosensory innervation to the external regions of the cochlear nucleus, and descending connections from other auditory structures to core regions of the cochlear nucleus. In addition to the normal innervation, her laboratory also study changes in these pathways after various forms of hearing loss, and their possible roles in tinnitus, loudness recruitment and central auditory processing.

 January 2013
Tuesday 15
13:00 - SEMINAR - Natural compounds as inhibitors of the 10 hallmarks of cancer : School of Anatomy, Physiology & Human Biology Raine Lecture More Information
Marc Diederich was awarded his PhD in molecular pharmacology in 1994 by the University Henri Poincaré Nancy 1, France. After training at the University of Cincinnati, USA, he focused his research on cancer and leukemia cell signaling pathways and gene expression mechanisms triggered by natural compounds with epigenetic-, anti-inflammatory- and cell death-inducing potential. Professor Diederich directs the Laboratory for molecular and cellular biology of cancer (LBMCC) at Kirchberg Hospital in Luxemburg. In 2012 he was appointed Associate Professor of Biochemistry at the College of Pharmacy of Seoul National University. Since 1998, he has been the organizer of the “Signal Transduction” meetings in Luxembourg. Professor Diederich’s research focuses on the development of novel anti-cancer drugs,for example, natural marine compounds which represent an interesting source of novel leads with potent chemotherapeutic or chemo-preventive activities. In the last decades, structure-activity-relationship studies have led to the development of naturally-derived or semi-synthetic analogues with improved bioactivity, a simplified synthetic target or less toxicity. Professor Diederich and his collaborators investigated for example chalcones that are aromatic ketones, known to exhibit anti-microbial, anti-inflammatory and anti-cancer activities. Organic sulfur compounds (OSCs) derived from plants, fungi or bacteria can also serve as chemopreventive and/or chemotherapeutic agents and attracted Professor Diederich’s interest as a promising source for novel anti-cancer agents.

 February 2013
Tuesday 05
17:00 - SEMINAR - WA Flow Group - Inaugural Meeting More Information
Inaugural Meeting of the WA Flow Group. Presentations by: Dr Senta Walton (Pathology & Laboratory Medicine UWA) "CD4+ T cells during MCMV infections'; Fiona Robins (Pathwest, Haematology) "CS&T application settings in diagnostic flow"; Dr Matt Linden (CMCA, UWA) "Flourish for panel design" Please RSVP for catering purposes.
Thursday 07
8:20 - SYMPOSIUM - DOHaD-Microbiome symposium : An exploration of the association between the microbiome and metabolome and the early life origins of health and disease More Information
This free symposium, open to all, has been organised by the microbiome working group of the DOHaD Consortium. A total of 16 speakers from throughout the University will cover a range aspects relating to metagenomics/metabolomics and early life origins of health and disease. Please RSVP for catering purposes.
Monday 18
9:00 - COURSE - Introductory Statistics : A short course using SPSS Website | More Information
The aim of this course is to introduce you to basic statistics. It will cover descriptive statistics (means and standard deviations); data exploration; basic categorical data analysis; simple linear regression and basic analysis of variance (ANOVA).

Subsidised rates are available for UWA Graduate Research Students.

Please register online.
Tuesday 26
13:00 - SEMINAR - The many shades of BARD1 in development and disease : School of Anatomy, Physiology & Human Biology Seminar Series More Information
The Seminar: For over more than a decade the research on BARD1 was a side-product of the research on the breast cancer gene and protein BRCA1. Co-expression of both proteins in most tissues, their similar structure, the same phenotypes in knock-out mice, and the hetero-dimeric complex formation of BRCA1 and BARD1 supported the commonly accepted few of BARD1 as an accessory protein of BRCA1. Work from my team was initiated with the assumption that BRCA1 and BARD1 proteins and genes might have common and separate functions. In recent years we discovered that differentially spliced forms of BARD1 are heavily overexpressed in many cancers. It appears plausible that BARD1 isoforms of different domain composition may be involved in the same pathways as FL BARD1, yet play a different role or compete for normal BRCA1-BARD1 functions. In my talk I will give an overview of the current state of research on BARD1, and, as far as possible within this given frame, on BRCA1. I will highlight the work from my group and provide the experimental evidence for the tumor promoting roles of aberrant forms of BARD1 that are associated with various types of cancer.

The Speaker: Irmgard IRMINGER-FINGER studied biology and biochemistry in Zurich, where she graduated in molecular biology and biochemistry and obtained a PhD in molecular genetics. After a three year postdoctoral period at the Molecular Cell Biology Department at the Harvard University, she returned to Switzerland and first had a position as independent researcher at the Biochemistry Department of the University of Geneva. In 1997 she moved into oncology at the Medical Faculty of the University of Geneva, having obtained a Swiss federal career development award. In 1998 she started her own research group focusing on the molecular pathways at the aging and cancer interface as part of the Biology of Aging Institute at the same institution. Since 2006 she heads the Molecular Gynecology and Obstetrics Laboratory at the Department of Gynecology and Obstetrics at the Geneva University Hospitals. The main interest of this laboratory is the function of tumor suppressor genes in normal and cancer cells and their implication in carcinogenesis and cancer progression, in particular the breast cancer genes BRCA1 and BARD1. Over the years, Dr. Irmgard Irminger-Finger built up her reputation as expert in the Cancer and Aging field and as expert on the BRCA1 and BARD1 genes, as author of scientific articles, speaker at conferences, organizer of meetings, editorial board member, and member of specific study groups and Task Forces.

Wednesday 27
12:00 - SEMINAR - School of Chemistry More Information
Mitochondrial responses to salinity in wheat and

Identification and characterisation of novel molecular regulators involved in phosphate metabolism in Arabidopsis thaliana and Oryza sativa

 March 2013
Tuesday 05
13:00 - SEMINAR - iVEC Supercomputing : School of Anatomy, Physiology & Human Biology Seminar Series More Information
The Seminar: This presentation will introduce you to the resources and expertise iVEC can provide to support your research. iVEC is encouraging the use of supercomputing, large scale data storage and visualisation for WA researchers. This is achieved by making available facilities and expertise to the research, education and industrial communities. Application areas include nanotechnology, radioastronomy, high energy physics, medical and mining training, medical research, mining and petroleum, architecture and construction, multimedia, and urban planning.

The Speakers:

Valerie is the Education Program Leader for iVEC. Valerie is responsible for training in supercomputing and eResearch along with internships and school outreach. She enjoys the challenge of communicating complex concepts to diverse audiences – breaking through the jargon to create a shared understanding. Valerie holds a PhD in Computer Science (SoftwareEngineering) and an honours degree in Computer Science.

Chris is a HPC Application Analyst and Parallel Programmer. He joins iVEC from Paratools, Inc. located in Eugene, Oregon where he was the Principle Investigator in several small business innovative research projects focused on developing HPC tools to support HPC application development and research.

Chris has also worked at University HPC centres both in the United States and in the United Kingdom as a Parallel Programmer. His career in High Performance Computing started at the Army Research Laboratory in Aberdeen, Maryland as an Application Analyst. He has a Masters degree in Scientific Computing at the Royal Institute of Technology in Stockholm, Sweden; while his undergraduate degree is in Mechanical Engineering from the University of Alabama in Huntsville.
Thursday 07
11:00 - SEMINAR - Environments for the Characterisation Community – MASSIVE and the Characterisation Virtual Laboratory More Information
The “21st century microscope” will not be a single instrument; rather it will be an orchestration of specialised imaging technologies, data storage facilities, and specialised data processing engines. This presentation will detail two complimentary national projects that are creating an integrated computer environment for researchers who work with imaging data. The Multi-modal Australian ScienceS Imaging and Visualisation Environment (MASSIVE – www.massive.org.au) is a specialised high performance computing (HPC) facility for computational imaging and visualisation. This facility provides the hardware, software and expertise to drive research in the biomedical science, materials research, engineering, and geoscience communities, and it stimulates advanced imaging research that will be exploited across a range of imaging modalities, including synchrotron x-ray and infrared imaging, functional and structural magnetic resonance imaging, x-ray computer tomography (CT), electron microscopy and optical microscopy. MASSIVE is a unique Australian facility with a focus on fast data processing, including processing data “in-experiment”, large-scale visualisation, and analysis of large-cohort and longitudinal research studies. The facility runs an instrument integration project to allow researchers to more easily process instrument data, and provides a remote desktop environment for researchers to use desktop tools to process, analyse and visualize their data. A major undertaking under the MASSIVE program, is the NeCTAR-funded Characterisation Virtual Laboratory (CVL), a project that is developing software infrastructure on the cloud to provide easier access to the tools and techniques that researchers use to process, analyse and visualise imaging data. The CVL is developing three exemplar platforms for multi-modal or large-scale imaging in neuroscience, structural biology, and energy materials. This presentation will describe MASSIVE and the CVL, highlight research that is being conducted using these environments, and describe how researchers can access them. Wojtek James Goscinski is the coordinator of the Multimodal Australian ScienceS Imaging and Visualisation Environment (MASSIVE), a specialist Australian high performance computing facility for imaging and visualization, and he is the External Collaborations Manager at the Monash e-Research Centre a role in which he promotes effective and creative applications of technology in research.
Tuesday 19
13:00 - SEMINAR - Kisspeptin, Fertility and Fatness : School of Anatomy, Physiology & Human Biology Seminar Series More Information
The Seminar: Jeremy’s work represents an exciting new field of neuroendocrinology. The recent discovery of mice and humans lacking the kisspeptin receptor (Kiss1R) and their subsequent infertility has sparked scientists to explore the actions of kisspeptin. Kisspeptin is a neuropeptide and regulates reproduction by signalling directly to GnRH neurons. In addition to being expressed in GnRH neurons, Kiss1R is also expressed in other brain areas, suggesting that kisspeptin may have additional functions outside of governing reproduction. New research has now uncovered that this peptide plays an equally exciting role in the control of adiposity.

The Speaker: Jeremy Smith began his research career at The University of Western Australia, where he completed his PhD with Distinction in 2004. In 2003, Jeremy was awarded a NICHD Fellowship (US) and began post-doctoral research at the University of Washington. Here, Jeremy worked extensively on kisspeptin, a novel neuropeptide, vital in the neuroendocrine control of GnRH secretion and reproductive function. In 2006, Dr Smith was awarded a NHMRC Biomedical Fellowship and returned to Australia to work at the Department of Physiology, Monash University. Jeremy has now returned to UWA and the School of Anatomy, Physiology and Human Biology to continue his work and is funded by the NHMRC, ARC and is a recipient of an ARC Future Fellowship.
Thursday 21
16:00 - SEMINAR - CMCA Seminar Series: "X-ray phase contrast imaging using conventional sources" by Dr Peter Munro More Information
Image contrast arises in conventional X-ray radiography due the differential absorption of X-rays throughout the sample. Many objects of interest, for example, soft biological tissue, possess weak absorption contrast. Furthermore, by definition, absorption contrast is directly correlated with the radiation dose received by the sample. X-ray phase imaging was developed, initially using synchrotron radiation, in order to overcome the limitation of weak absorption contrast. This technique develops contrast based upon the difference in X-ray propagation times through a sample, which, in general, results in greater contrast than absorption based imaging. In this seminar I will discuss how X-ray phase imaging can be performed using conventional X-ray sources such as those used in clinics and give examples from a variety of fields including mammography, non-destructive testing, security screening and small animal imaging.
Tuesday 26
13:00 - SEMINAR - Bending strains in long bones: The case of the xenarthran third trochanter. : School of Anatomy, Physiology & Human Biology Seminar Series More Information
The Seminar: The femur of armadillos and their fossil relatives, the glyptodonts is characterised by a large third trochanter projecting from the lateral side of the shaft. The role of this prominent structure and the muscles that attach there is unknown. This presentation looks at the variation in the shape the xenarthran femur and explores the hypothesis that the third trochanter plays a role in regulating coronal plane bending strains in these strange animals.

The Speaker: Nick Milne began his research career in the 1980s looking at the uncinate processes of cervical vertebrae. He was interested in what role they played in the human neck and turned to comparative anatomy and function to try to understand these structures in a broader context. His interest in the comparative structure and function of bones has continued and collaborations with South American palaeontologists led to a fascination with armadillos and their strange glyptodont and ground sloth relatives. Collaborations with Paul O’Higgins in the UK have led to the application geometric morphometric and finite elements analysis techniques to try to understand aspects of xenarthran structure and function.

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