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Today's date is Tuesday, September 22, 2020
School of Molecular Sciences
 July 2012
Monday 09
13:00 - VISITING SPEAKER - Towards a blueprint of leaf development in C3 and C4 plants : The establishment of the C4 syndrome requires alterations in leaf anatomy, biochemistry and leaf development. More Information
We hypothesize that the massive changes in C4/C3 related gene expression are controlled by a subset of transcriptional regulators, which are essential for C4 photosynthesis establishment and/or maintenance. We analyze the Cleome genus, which includes closely related C4 (Cleome gynandra) and C3 (Cleome hassleriana) species and exhibits phylogenetic proximity to the model species Arabidopsis thaliana.In order to elucidate the regulatory network behind the C4 syndrome in Cleome we are employing two strategies: (i) A single candidate gene approach derived from a global comparative analysis of transcriptome data sets of C4/C3 species (including Cleome hassleriana and gynandra) generated by 454 and Solexa sequencing, which targets will be further described biochemically and genetically (e.g. via over-expressor and knock-out lines in Arabidopsis thaliana) and (ii) co-expression analysis for the identification of the regulatory modules which will include a developmental gradient of photosynthetic and a subset of non-photosynthetic tissues.
Tuesday 10
12:00 - SEMINAR - School of Chemistry and Biochemistry Seminar : From Molecular Motors To Fungal Intelligence More Information
Protein molecular motors are natural nano-machines that convert the chemical energy obtained from the hydrolysis of adenosine triphosphate (ATP) into mechanical work which is central to cellular motion, muscle contraction, cell division and a multitude of other critical biological processes. Remarkably, protein molecular motors differ fundamentally from artificial devices in that the conversion from chemical energy to mechanical energy is done directly, rather than via an intermediary state as in e.g., heat for thermal engines. This fundamental difference results in a far better efficiency (close to 100%, for both linear and rotary motors) of these natural mechanical devices compared to artificial ones. This exceptional efficiency, together with the small scale of protein molecular motors, has prompted an increasing number of studies focused on their integration in hybrid micro- and nanodevices. However, and despite tremendous progress in the engineering of molecular motors, much needs to be learnt from Nature, in particular regarding the cooperative behaviour of molecular motors in vivo, before coming even close to efficiency in in vitro devices.

Filamentous fungi are very successful in colonizing micro-confined maze-like networks (e.g., soil, wood, leaf litter, plant and animal tissues), suggesting that they may be efficient solving agents of geometrical problems. The growth behaviour and optimality of space-searching algorithms of several fungal species has been tested in microfluidic mazes and networks. First, it was found that the growth behaviour of all species was strongly modulated by the geometry of micro-confinement. Second, the fungi used a complex growth and space-searching strategy comprising two algorithmic subsets: (i) long-range directional memory of individual hyphae and (ii) inducement of branching by physical obstruction. Third, stochastic simulations using experimentally measured parameters showed that this strategy maximizes both survival and biomass homogeneity in micro-confined networks, producing optimal results only when both algorithms are synergistically
Wednesday 11
12:00 - EVENT - School of Chemistry and Biochemistry Seminar : The Chemistry and Physics of Charge-Resonance More Information
Organic dyes with a charge-resonant electronic structure (for example, Michler’s Hydrol Blue, below) are venerable molecules, having played a critical role in the development of the synthetic chemical industry. More recently, they have attracted attention because the environmental sensitivity of their optical response makes the useful as molecular sensors and markers. The fluorescence quantum yield of dyes can be modulated over six orders of magnitude in different environments. Large variations in the nonlinear optical response are also observed. In my talk, I will discuss the chemical and physical concepts underlying the notion of charge-resonance, and describe its mathematical formulation. I will show explicitly that relatively simple 2- and 3- state models based on these concepts can be used to understand and even predict the results of quite complicated and high-level computational quantum chemistry calculations. I will show that models based on the concept of resonating charge forms, which were originally designed to model the color of dye molecules, can also be applied to understand apparently unrelated properties e.g. their nonlinear optical response and also their nonradiative decay behavior. These properties are important to understanding the use of these dyes in several very recent applications, which I will also discuss.

Thursday 12
12:00 - SEMINAR - School of Chemistry and Biochemistry Seminar : Macrocycles: conformation that dictates biological activity More Information
Urukthaplestatin A (Ustat A) is a novel natural product, consisting of oxazoles and thiazoles inbedded in a macrocycle. It has extraordinary cytotoxicity against cancer cells in the desirable low nanomolar range (average GI50 = 5.6nM). It does not share structural homology with other classes of marketed cancer therapeutics, and it has a different activity profile to compounds with structural similarities indicating a possible novel and unique mechanism of action. We use novel, modular oxazole methodology that generates numerous Ustat A analogs, and specifically we have designed compounds that will explore its structure-activity relationship and mechanism of action. Given the cytotoxicity and the novelty of these molecules, they are ideal starting points for developing new cancer therapies.

Molinski and co-workers discovered Sanguinamide B (San B) from a single species of nudibranch. The San B natural product contains two thiazoles and one oxazole, and is a modified octapeptide macrocycle; unlike other natural products isolated from this sponge, San B contains two proline residues, where these two residues are control the conformation of the macrocycle. The potent cytotoxic and antibiotic properties of other macrolides isolated from this nudibranch species, and the small microgram quantities of the compound that are available from the natural source, make this natural product a very attractive compound to synthesize. We have synthesized and tested San B and numerous analogues against gram +ve, gram –ve bacteria as well as against mammalian cancer cell lines. Not surprisingly, the conformation of these compounds dictates their biological activity.

Wednesday 18
10:00 - VISITING SPEAKER - The Transition from Health to Sickness - the role of plant hormones in underpinning plant pathogen virulence strategies : Speaker will also present at CSIRO Floreat on previous day. More Information
"Our research focuses upon how the virulent bacterial phytopathogen Pseudomonas syringae establishes disease in the model plant Arabidopsis thaliana. P. syringae delivers a suite of ~ 30 effector proteins into the plant cell." Detailed abstract available [email protected]

12:00 - SEMINAR - School of Chemistry and Biochemistry Seminar : Towards Enzyme Enhancement Therapies for Gaucher Disease More Information
Gaucher disease (GD) is a rare genetic disorder characterized by the accumulation of β-D-glucosylceramide within the lysosomes of the cell. This occurs because of insufficient lysosomal glucocerebrosidase (GBA) activity, which is a direct result of mutations in the encoding gene. Some common GD-causing mutations do not significantly diminish GBA’s catalytic competence in a direct manner, but instead deleteriously affect folding and trafficking of the enzyme. These mutant enzymes have difficulty obtaining and retaining their native fold within the lumen of the endoplasmic reticulum (ER), and so most of the enzyme undergoes ER-associated degradation rather than reaching maturity and being trafficked to the lysosome. Small molecules that bind to and stabilize correctly folded mutant enzyme within the ER may elevate the steady-state concentration of folded enzyme within this organelle and increase the amount of enzyme trafficked to lysosomes, potentially ameliorating the disease. This emerging approach to treating GD is known as enzyme enhancement therapy and requires the development of small molecule ‘pharmacological chaperones’. Efforts to develop such compounds will be detailed in this seminar.
Tuesday 24
9:00 - COURSE - Linear Regression and ANOVA : A Short Course using IBM SPSS Website | More Information
The course is designed for people with knowledge of basic statistics who want to learn more about regression and analysis of variance (ANOVA).

The course is hosted by the Centre for Applied Statistics and we offer discounted rate fees to UWA Graduate Research Students.

Fee information is available on our website cas.maths.uwa.edu.au. Please register online.
Wednesday 25
12:00 - Competition - Three Minute Thesis Final : 10 PhD students will explain their research and its significance in just 3 minutes each. Website | More Information
The 3MT competition challenges research students to give a dynamic and engaging presentation about their research and its significance in a way that can be understood by everybody. The audience will select the "People's Choice" winner.
Thursday 26
9:00 - COURSE - Logistic Regression and Survival Analysis : A Short Course using IBM SPSS Website | More Information
The course is designed for people with knowledge of basic statistics who want to learn more about how to analyse binary or survival data.

The course is hosted by the Centre for Applied Statistics and we offer discounted rate fees to UWA Graduate Research Students.

Fee information is available on our website https://www.cas.maths.uwa.edu.au/courses. Please register online.
Monday 30
12:00 - SEMINAR - LIWA Medical Research Seminar Series : Prof Geoff Laurent presents "Stem cells and lung regeneration" Website | More Information
LIWA invites you to a free seminar on: "Stem cells and lung regeneration" by Professor Geoff Laurent, Director, Centre for Cell Therapy and Regenerative Medicine, UWA. Time: 12 noon for light lunch with 12.30pm – 1.30pm presentation.
Tuesday 31
17:00 - EVENT - Mother's eating habits affect her daughters' milk production : Public lecture on the effects of fetal programming and their transmission to offspring Website | More Information
What makes a healthy start to life? This is the single overarching question and focus of the NRCD, a New Zealand government-funded Centre of Research Excellence, bringing together leading scientists from six organisations across New Zealand to answer this question. Acting Director, Prof Hugh Blair, is leading several projects investigating the effects of fetal programming on later life productivity in sheep and cattle and the possibility that these programming effects may be transmitted between generations. His public lecture examines how this applies to sheep, focusing on how a mother's eating habits affect her daughters' milk production.

 August 2012
Wednesday 01
14:00 - SEMINAR - In Vivo Pre-Clinical imaging using Optical Light More Information
With the recently acquired IVIS Lumina and Maestro instruments at UWA, researchers now have the ability to longitudinally and non-invasively monitor cancer (and other disease states) in small animal models using optical light. This seminar is intended to provide a high-level overview of the capabilities on the instruments, as well as answer any user specific questions. Focus areas will include: Monitoring tumour growth, Stem Cell research and Atherosclerosis, Tracking gene expression
Tuesday 07
13:00 - SEMINAR - Prenatal glucocorticoids, placental development and neurological function : School of Anatomy, Physiology and Human Biology Seminar Series More Information
The Seminar: Fetal glucocorticoid exposure is a key mechanism proposed to underlie prenatal "programming" of adult cardiometabolic and neuropsychiatric disorders. Regulation of fetal glucocorticoid exposure is achieved by the placental and fetal glucocorticoid "barrier," which involves glucocorticoid inactivation by 11beta-hydroxysteroid dehydrogenase 2 (11beta-HSD2). Mice null for 11beta-HSD2 exhibit altered placental development and function, decreased birth weight, delayed neurodevelopment and increased anxiety and depressive-like behaviour as adults. This raises the question as to whether it is placental or fetal brain 11b-HSD2 that underpins programmed outcomes? Preliminary data suggest that fetal brain 11beta-HSD2 impacts specifically on depressive-like behaviours, but that broader anxiety-related and neurodevelopmental effects are likely to relate to indirect effects of 11-HSD2 in the placenta.

The Speaker: Caitlin completed her PhD at UWA under the supervision of Prof Brendan Waddell and Dr Peter Mark, where she focused on developmental programming and the significance of omega-3 intake in attenuating adverse health outcomes. Caitlin moved to Edinburgh in 2006 to take up a postdoctoral position at The Queen's Medical Research Institute. Here she continued her research interest in developmental programming in the lab of Prof Jonathan Seckl and Prof Megan Holmes. Caitlin then returned to Perth in late 2011 to commence an Assistant Professor position at The School of Anatomy , Phsiology and Human Biology at UWA.
Sunday 12
10:00 - EVENT - 2012 Open Day : Experience what's on offer at UWA Website | More Information
UWA opens up the whole campus to the public.

Come and find out about the courses on offer, career options, scholarship opportunities, our valuable research, community programs and facilities.

There's also residential college tours, hands-on activities, live music and entertainment, and plenty of fun activities for the whole family.

11:00 - EVENT - SCINEMA Film Festival : Science films showing on Open Day in the Science Library Foyer More Information
As part of National Science Week, the Science Library is once again hosting the SCINEMA Film Festival

Two collections of short films on selected topics will be screened in the Science Library Foyer during Open Day, and they are as follows:

11:00am - 12:45pm - ‘A Climate for change’

12:50pm - 3:00pm - ‘Space & Astronomy’

Entry to enjoy these two collections of films is free, so come along and enjoy!
Thursday 16
16:00 - VISITING SPEAKER - RNA editing and DYW-type PPR proteins as specificity factors in mitochondria of the moss Physcomitrella patens and the protist Naegleria gruberi : Numerous cytidines are converted into uridines by site-specific RNA editing of mitochondrial and chloroplast transcripts, which corrects genetic information in land plants. More Information
In flowering plants, mitochondrial transcriptomes contain some 300–500 RNA editing sites and chloroplast transcriptomes approximately 30 editing sites. In lycophytes, RNA editing is particularly abundant with more than 2100 editing sites in mitochondrial mRNAs and rRNAs of the spikemoss Selaginella moellendorffii. In contrast, only 11 sites are identified in mitochondria of the model plant Physcomitrella patens, making this moss an attractive model for functional studies. Pentatricopeptide repeat (PPR) proteins with unique carboxyterminal extensions (E/DYW) encoded by extended nuclear gene families in plants have previously been characterized as specificity factors recognizing editing sites. PPR proteins with the DYW domain in particular were shown to perfectly correlate with the presence of RNA editing in evolution. Our DYW-PPR gene knockout studies in Physcomitrella will contribute to identify the full set of nuclear specificity factors addressing all editing sites in a plant mitochondrial transcriptome. Most surprisingly, we recently also identified DYW-type PPR proteins in the heterolobosean protist Naegleria gruberi. Interestingly, we were now able to identify C-to-U editing in the mitochondrial transcriptome of this protist, which is phylogenetically separated from the plant lineage by more than 1 billion years of evolution.
Tuesday 21
13:00 - SEMINAR - Stroke and cerebral ischaemia: exploring potential neuroprotective strategies : School of Anatomy, Physiology & Human Biology Seminar Series More Information
The Seminar: We have previously reported that treatment with magnesium following global and focal cerebral ischaemia does not reduce brain damage in normothermic rats (1, 2). However we have shown that mild hypothermia (35°C) combined with magnesium is more effective than either treatment used alone following global and focal ischaemia (3). Treatment is effective when commenced 2 hours post global ischaemia and when commenced 2 or 4, but not 6 hours post-permanent focal ischaemia (4). We are currently further defining therapeutic windows following global ischaemia and transient focal ischaemia.

The Speaker: Bruno Meloni obtained his Bachelor of Science degree at Curtin University in 1985 and his PhD degree at Murdoch University in 1993. In 1996, he started a second Postdoctoral position with the newly formed Stroke Research Group, situated at the ANRI and headed by Clinical Professor Neville Knuckey. A/Prof Meloni was responsible for setting up the molecular biology, in vitro cultivation and animal surgery laboratories and has played a major role in overseeing its direction over the last 15 years. A/Prof Meloni's research has focussed on identifying neuroprotective proteins for the development of potential treatments for ischaemic brain injury and assessing the effectiveness of mild hypothermia and magnesium as a neuroprotective therapy following cerebral ischaemia. To this end, his talk will focus on experimental work performed by the Stroke Research Group over the last several years characterising the efficacy of mild hypothermia and magnesium in stroke and global cerebral ischaemia rat models.
Thursday 23
17:00 - WELCOME - NEW ACADEMIC STAFF MEMBER! "By Way of Introduction" : Dr Mylne is soon to join UWA as an ARC Future Fellow. More Information
Currently at University of Queensland, Dr Mylne will speak about his past, current and future plans for his Fellowship at UWA. Welcome Dr Mylne! "At UWA I intend to focus on three areas; 1) study the various genetic ‘innovations’ that create these ultra-stable peptides, 2) hone in on the in vivo biochemical process that produce such biomedically relevant peptides; and 3) develop a new biological system to discover the elusive biochemical targets of important anti-malarials drugs." DETAILED CV AVAILABLE !!! email [email protected]
Friday 24
8:30 - CONFERENCE - Combined Biological Sciences Meeting 2012 : Full day meeting for all members of the life sciences community Website | More Information
CBSM aims to promote biological science in Western Australia by encouraging the interaction of scientists, students and industry representatives from all aspects of life science.

The meeting is designed to provide a platform for the exchange of ideas and expertise to keep the life sciences in WA at the cutting edge. This annual meeting includes plenary presentations by national and international scientists and in 2012 will incorporate concurrent specialist symposia each with its own keynote speaker and session of local senior scientists.

CBSM is also geared toward students and the development of students among their peers. Several sessions are set aside for student presentations and for many it represents their first chance to present their work in a conference setting. These honours and post-graduate students work in universities, research institutes, and industry around Western Australia. In this way CBSM offers a unique “snapshot” of what is happening in local biological science and now attracts 250-300 delegates every year, with nearly 40 oral presentations, over 70 scientific posters and 30 trade booths. Check out the program at www.cbsmwa.org.au/program.

So where will you be on Friday the 24th of August? Join us at the University Club, The University of Western Australia for CBSM 2012!

www.cbsmwa.org.au - [email protected]
Monday 27
10:00 - WORKSHOP - Flow Cytometry Data Analysis More Information
This workshop is recommended to anyone who is currently using or is thinking of using FlowJo for flow cytometry data analysis. The sessions will be very informative and you will pick up some new tricks! Sessions include: 10.00 am Basic Functionality, Groups Layouts, Tables, Batching, and 11.00am Compensation, Transforms, Advanced Analysis Platforms

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