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Today's date is Wednesday, November 25, 2020
School of Molecular Sciences Seminars
 May 2019
Friday 31
12:00 - SEMINAR - Bayliss Seminar Series : Andrew Marshall: The reducer, the acetylator and the DNA replicator - Structural studies on essential Aspergillus fumigatus proteins. More Information

12:00 - SEMINAR - Bayliss Seminar Series : Andrew Marshall – UWA Bond Lab More Information

 June 2019
Wednesday 05
11:00 - SEMINAR - Bayliss Seminar Series : Professor Luigi Cavallo - Tuning Vicinal and Remote Steric Effects in the Rationalization of Catalytic Behavior More Information

13:00 - SEMINAR - Postgraduate Showcase: Frontiers in Agriculture Website | More Information
Each year The UWA Institute of Agriculture hosts a postgraduate showcase where some of UWA's top PhD students present their research in agriculture and related areas. Join us for an afternoon of fantastic talks from seven PhD students in the UWA School of Agriculture and Environment, the UWA School of Molecular Sciences, and the UWA Law School, with an introduction by Prof Imelda Whelehan, Dean, Graduate Research School. Afternoon tea and refreshments provided.
Friday 07
12:00 - SEMINAR - Bayliss Seminar : Professor Norbert Jux – Carbon-rich porphyrins More Information
Thursday 13
12:00 - SEMINAR - Bayliss Seminar Series : Grishma Vadlamani - Understanding the structure and function of proteins involved in inducible AmpC β-lactamase resistance More Information
The inducible expression of AmpC β-lactamase is a major cause of β-lactam antibiotic resistance in several clinically relevant Gram-negative bacteria, including the opportunistic pathogen Pseudomonas aeruginosa. AmpC induction is regulated by the transcriptional regulator AmpR, which binds to the divergent ampR-ampC operon and is activated by 1,6-anhydromuramoylpeptide – an anabolite of peptidoglycan (PG) recycling that is generated by the N-acetyl-β-glucosaminidase NagZ. I will be sharing my findings into the molecular basis of ampC induction based on the structural and biophysical characterization of the archetypal AmpR protein from Citrobacter freundii (CfAmpR). CfAmpR forms a homotetramer that is stabilized by binding the intergenic region of the ampR-ampC operon, and it interacts with up to four repressor ligands (UDP-MurNAc-pentapeptide) in an apparent stepwise manner. Since NagZ generates the AmpR activator ligand, blocking its activity enhances β-lactam efficacy against bacteria with inducible AmpC systems. Crystal structures of NagZ from Burkholderia cenocepacia were determined in complex with the glycosidase inhibitor O-(2-acetamido-2- deoxy-D-glucopyranosylidene)-amino-N-phenylcarbamate (PUGNAc) and its NagZ-selective derivative ethylbutyryl-PUGNAc, 3-acetamido-4,5,6-trihydroxyazepane (MM-124) and its NagZ-selective derivative MM-156, showing that plasticity within the NagZ active site could be exploited to improve the design of inhibitors that selectively bind NagZ over functionally related human N-acetyl-β-glucosaminidases. Furthering an understanding of the role of NagZ inhibition on β-lactam resistance in P. aeruginosa, it was found that the NagZ inhibitor PUGNAc could prevent the emergence of high-level AmpC-mediated β-lactam resistance, and significantly enhanced β-lactam susceptibility in synergy with the potent β-lactamase inhibitor avibactam in an ampC derepressed P. aeruginosa strain. Collectively, this talk offers key insights into the regulatory mechanism of AmpC β-lactamase expression and explores small molecule based strategies to potentiate β-lactam efficacy against Gram-negative bacterial pathogens.
Wednesday 19
12:00 - SEMINAR - Bayliss Seminar : Professor Rita Bernhardt – Uni of Saarlandes, Germany More Information

 July 2019
Wednesday 03
13:00 - SEMINAR - Deconstructing, replicating and engineering instructive niches for stem cell differentiation : School of Human Sciences Seminar Series More Information
Abstract: Most cells in our bodies are embedded in a complex matrix of extracellular molecules. These tissue-specific and dynamic microenvironments are essential for the functioning of the cells. But exactly what these microenvironments, or so-called "cell niche", are doing to the cells? Can we capture the "design principles" of these complex matrices on engineered microsystems, and guide in vitro cultured cells to form and function as a tissue? Traditional two-dimensional cell culture systems have been used to investigate the roles of tissue microenviroments. But these experimental systems are often too simplistic to reflect the complexity of the natural microenvironment. On the other hand, native tissue microenvironments, such as those provided by decellularised organs, are too complex to be reverse-engineered into model systems that can be studied and applied. This talk summarises our lab's recent attempts to deconstruct tissue microenvironments into their biochemical and architectural components, and investigate the roles of each components in guiding adult stem cell differentiation. The objective of this seminar is to introduce an interdisciplinary audience to the nature and challenges of our research question, and to present some of the approaches we are using to tackle it. Discussion with the cell biologists, bioengineers, materials scientists after the talk will hopefully bring forth fresh and creative ideas on this project.

17:45 - Information session - MBA and Graduate Certificate Information Evening : Find out about UWA MBA and Graduate Certificate courses on offer. Website | More Information
Are you ready to transform your career?

Join us at the next MBA and Graduate Certificate information evening.

Discover your study options and entry pathways into the UWA MBA, plus find out about the program's networking opportunities, access to industry professionals, personalised career mentorship and international study tours.

Meet our MBA Director, Allan Trench, as well as students currently in the program, alumni who've completed their course, and your future lecturers in the UWA Business School, to gain an insight of what life as an MBA candidate is really like.

5:45pm: Registrations open; 6:00pm: Presentations by current students, alumni and MBA Directors; 7:00pm: Networking, drinks and opportunity for your questions to be answered.

Registrations essential online: https://study.uwa.edu.au/events/mba-information-evening-3-july
Thursday 18
12:00 - SEMINAR - Bayliss Seminar Series : Development of New Polymyxin Antibiotics Targeting Gram-negative 'Superbugs' More Information
Postponed until November
Friday 19
12:00 - SEMINAR - Bayliss Seminar Series : Microbes and transition metals: insights into manganese and gold biogeochemical cycling More Information
Thursday 25
12:00 - SEMINAR - Bayliss Seminar Series More Information
Microbes and transition metals: insights into manganese and gold biogeochemical cycling

12:00 - SEMINAR - Bayliss Seminar Series : Microbes and transition metals: insights into manganese and gold biogeochemical cycling More Information
Tuesday 30
12:00 - SEMINAR - Multimodal Preclinical Imaging- High Frequency Ultrasound and Photoacoustic Imaging : Applications of High Frequency Ultrasound and Photoacoustic Imaging- Now available at the Centre for Microscopy, Characterisation and Analysis More Information
Applications of High Frequency Ultrasound and Photoacoustic Imaging in small animals- Cardiovascular Imaging & Analysis, Cancer Imaging, Kidney, Liver & Other Abdominal Organs, Reproductive, Embryo & Neonate Imaging, Ophthalmic Imaging, Image-Guided Needle Injections, Microvascular Perfusion with Contrast Agents,Molecular Imaging Techniques.

 August 2019
Friday 02
12:00 - SEMINAR - Bayliss Seminar Series : Mechanism and Application of Microbial Extracellular Electron Uptake Process More Information
Mechanism and Application of Microbial Extracellular Electron Uptake Process
Thursday 08
12:00 - SEMINAR - Bayliss Seminar Series More Information
X-ray diffraction and scattering at Curtin University: Big stuff, small stuff, hot stuff, cold stuff
Thursday 15
12:00 - CANCELLED - SEMINAR - Bayliss Seminar Series More Information
Unfortunately this event has been cancelled.

THIS SEMINAR HAS BEEN CANCELLED

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Molecular Phenotyping in Precision and Preventive Medicine
Friday 16
14:00 - SEMINAR - Bayliss Seminar Series : Dr Alastair Stewart, Laboratory Head, The Victor Chang Cardiac Research Institute, Sydney More Information
“Cryo-EM studies of E. coli F1Fo ATP synthase”
Monday 19
14:00 - SEMINAR - Bayliss Seminar Series : Prof. Dr Albrecht Berkessel More Information
Catalytic synthesis with titanium and Carbenes
Thursday 22
12:00 - SEMINAR - Bayliss Seminar Series : Tracey McClurg - APR Intern business development manager More Information
APR Intern connects Australia’s biggest problem solvers from a range of disciplines, enhancing the PhD experience of students by giving them the opportunity to apply their research skills within an industry context.


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