What's On at UWA

Gauge your readiness for the GAMSAT! We'll be providing free handouts with sample practice questions. You will then be asked to take a short timed practice test followed by a discussion of the worked solutions.

Our GAMSAT free seminars are like mini versions of our live attendance courses. We focus on teaching the most important strategies for each section rather than a mere overview of the GAMSAT.

Note: It is not necessary to be using Gold Standard GAMSAT products in order to attend this free GAMSAT seminar. You will receive a free handout but please bring some writing paper.

The Gold Standard GAMSAT textbooks are available at the UWA Co-op Bookshop as well as at www.gamsat-prep.com.

UWA academics are cordially invited to the inaugural ‘Lunch & Learn’ event run by our new UWA ‘Teaching Innovations’ Community of Practice. The focus of this event will be VR in Higher Education. The event will be held on Wednesday 30th January, 2019 from 12 noon to 1.30pm in the Fay Gale Studio (formerly the Carpe Diem Studio) in the Educational Enhancement Unit.

This informal 90 minute session will include insights into the AR, VR and Mixed Reality programs currently enhancing student learning across the university, and a panel discussion at the end. The aim is to share expertise in this area across disciplines and to inspire others to consider incorporating VR into teaching to enhance student engagement and outcomes. This will be a supportive environment where you will be encouraged to engage in cross-disciplinary interaction and collaboration.

Lunch will be provided. Please rsvp for catering purposes by 28 January 2019 to: https://www.eventbrite.com/e/community-of-practice-innovation-lunch-learn-tickets-55144112525?utm_source=eb_email&utm_medium=email&utm_campaign=new_event_email&utm_term=viewmyevent_button

Epigenetic switching and antisense transcription

Regulation and function in non-coding RNAs in cardiovascular disease

2D Gas Sensors with High Sensitivity and Selectivity: Insight from Theoretical Simulations

Particle methods have capabilities that particularly suit numerical simulation of complex phenomena involved in industrial and biophysical application domains. The two core methods used in this talk are DEM (Discrete Element Method) and SPH (Smoothed Particle Hydrodynamics). Coupling of these methods also provides powerful capabilities to model multiphase behaviour. Industrial application to crushing and grinding, mixing and water cooling will be presented. Coupling to biomechanical models allows simulation of humans interacting with their environment. Examples of elite swimming, diving, kayaking and skiing will be shown. The use of these methods to simulate digestion (from breakdown in the mouth through stomach) and intestines will also be discussed.

Jennifer Young (Dual gradient hydrogel systems for mechanobiology applications): The spatial presentation of mechanical information is a key parameter for cell behavior. We have previously developed a method for creating tunable stiffness gradient polyacrylamide hydrogels with values spanning the in vivo physiological and pathological mechanical landscape. Importantly, we created gradients that do not induce durotaxis in human adipose-derived stem cells (hASCs), thereby allowing for the presentation of a continuous range of stiffnesses in a single sample without the confounding effect of differential cell migration. Using these nondurotactic gradient gels, stiffness-dependent hASC morphology, migration, and differentiation were studied, providing high resolution data on stiffness-dependent expression and localization. Expanding upon this work, we are utilizing these gradient hydrogel systems to study cancer cell-ECM interactions. Interactions with the surrounding microenvironment have been shown to positively influence cancer cell survival and invasion by conferring adhesion-based resistance in response to chemotherapeutic drugs, and subsequently driving metastasis into surrounding tissues. In order to study a wide range of ECM environments, we produce dual-gradient systems by fabricating a gradient of ligands on top of our previously described stiffness gradient hydrogels. Ligand gradients are produced by either a gradient photomask to which proteins can be coupled to the substrate via a UV-sensitive crosslinker or by depositing a gradient of gold nanoparticles onto the hydrogel to which thiolated peptides can readily attach. Using these dual gradient hydrogels, we can better understand the interplay of substrate stiffness, ligand type, and ligand spacing in regulating adhesion-conferred chemoprotection in cancer cells. Andrew W. Holle (Under pressure: the role of multidimensional confinement in mechanobiology): As bioengineers systematically move from simple 2D substrates to more complex 3D microenvironments, the role of cellular and nuclear volume adaptation in response to these substrates is becoming more appreciated. Long, narrow PDMS microchannels, which recapitulate porous extracellular matrix (ECM) networks found in vivo, confine cells to a single axis of migration and require them to utilize a complex synergy of traction force, mechanosensitive feedback, and subsequent cytoskeletal rearrangement. This process exhibits characteristics of the poorly understood mesenchymal-to-amoeboid transition, in which cells alter their migratory phenotype in order to traverse narrow constrictions and more successfully metastasize. During channel permeation, the volume of the nucleus changes, suggesting that nuclear reorganization and volume adaptation is a key step for successful permeation. Volume adaptation is also an important phenomena in stem cell mechanobiology. 3D GelMA hydrogel scaffolds with linear stiffness gradients were used to confine stem cells in three dimensions, with cells in the soft end more able to deform the matrix and increase their cell volume, while those on the stiff end were more confined. Cells on the soft end, which were able to adapt their volume more efficiently, exhibited markers for osteogenesis, while those on the stiff end became more adipogenic. This trend, which is opposite to what is observed on 2D hydrogels, suggests that volume adaptation, not stiffness, is sufficient for mechanosensitive differentiation in 3D. Ultimately, as volume adaptation is ubiquitous in 3D microenvironments in vivo, new tools will lead the way in analyzing and understanding mechanobiology.

There is a rapidly growing interest among agricultural research to work in international development. Certainly, it is an extraordinary field, filled with challenges, yet bringing enormous rewards. Some key questions that many enthusiasts face are:

How do I get involved?

What does a career in international development entail?

Which organisations exists and what do they do?

If any of the above ring a bell to you, please join us in our next RAID event. Researchers in Agricultural for International Development (RAID) is an Australia-wide network aimed at connecting, supporting and engaging with researchers with an interest in this space.

Please, join us on 7 March to meet and learn from top leading researchers in the field:

Dr Deborah Prichard: Senior Lecturer, Department of Environment and Agriculture, Curtin University

- Prof. Richard Bell: Professor in Land Management and leader of the Land Management Group at Murdoch University

- Prof. Kadambot Siddique: Hackett Professor of Agriculture Chair and Director, The UWA Institute of Agriculture

- Dr Eloise Biggs: Lecturer, Faculty of Science, UWA School of Agriculture and Environment

- Prof. Tim Colmer: Acting Pro Vice-Chancellor (Research), UWA School of Agriculture and Environment

- Dr David Mickler: Interim Director of the UWA Africa Research & Engagement Centre (AfREC) and Senior Lecturer in Foreign Policy & International Relations in the School of Social Science, UWA

- Em Prof. Lynette Abbott: Senior Honorary Research Fellow, UWA School of Agriculture and Environment, Crawford Fund WA Committee Coordinator

- David Windsor: Consulting Agricultural Scientist, WA Chair AG Institute Australia

Speakers will talk about their own experiences and provide tips on how to get actively involved in agricultural research for international development. The event is aimed at CONNECTING people with a common passion, so we encourage all attendees to participate in the networking after the talks. Nibbles and drinks will be provided.

The RAID team look forward to seeing you at the event!

Note: There is free parking in and around campus after 5pm.

An Australian robotics company, ST Solutions, will present a talk on how to use its product, "Pepper", a communication robot for research, teaching, and outreach activities. There will be a robot demonstration using Pepper.

We’re hosting an event in support of the national charity R U OK? because we believe that asking “are you ok?” is something we can all do to make a difference. On March 19th, the Science Student Office, Science Union and SNAGS will be holding our R U OK? Day to inspire that simple but important question “are you ok?” Free BBQ and drinks provided

Migrants to Australia often experience diverse health and mental health needs which may not be met by mainstream services. Addressing such needs involves understanding complex social and cultural specifics. Instead of treating people as generic bodies, a social approach to health recognises that individual and collective histories, migration stories, settlement conditions, cultural practices and social positioning affect health outcomes. Taking social perspectives into account can help us ensure inclusive health and mental healthcare. So what are the key issues? And what are the solutions? Essential by registering online at https://bit.ly/migrant-health-uwa by Monday 18 March 2019

Abstract: Melanoma is the fourth most commonly diagnosed cancer in Australia, resulting in ~1500 deaths each year. While extensive public health campaigns have increased community awareness of the importance of sun-safety and skin monitoring, a substantial number of melanomas remain undetected until late-stage progression. New treatments that harness the immune system offer great promise for melanoma treatment, but further advances are required for these approaches to succeed in the majority of patients. Immunotherapy strategies use a variety of approaches to harness T cell immunity to control melanoma. We have recently identified several new settings of effective T cell cancer surveillance, resulting in either complete elimination of malignant cells or the establishment of a dynamic ‘melanoma-immune equilibrium’. This fundamental knowledge should be of value for the development of novel clinical strategies targeting cancer.

Speaker: Dr. Jason Waithman is a molecular and cellular immunologist having obtained his PhD in 2008. His training was completed in outstanding institutions that include the University of Melbourne, Walter and Eliza Hall Institute, and Ludwig Institute for Cancer Research under the guidance of multiple international leading immunologists. He relocated to Perth in 2012 to establish and run an independent, original research program at the Telethon Kids Institute. He has successfully attracted fellowship support from 2010-21 and has attracted project funding from multiple sources to support his research program. He is currently working closely with an industry partner and the host institute to develop innovative therapeutic techniques for cancer patients as part of the discovery and translation pipeline associated with his research program.

Melanotransferrin (MTf) is a membrane-bound transferrin homologue that is found in melanoma cells and was one of the first melanoma tumour antigens to be characterized. It possesses an iron-binding site like the iron-binding protein in the blood, transferrin, but does not play a role in normal cellular iron metabolism. This was shown by Richardson through a variety of studies in vitro in cell culture and in vivo using purpose generated melanotransferrin knockout and transgenic mice. However, Richardson later demonstrated that melanotransferrin stimulates melanoma growth, proliferation and migration and more recently appears to play an exciting role in oncogenic signalling via down-regulating the metastasis suppressor protein, NDRG1. Intriguingly, over-expression of NDRG1 can down-regulate MTf. The studies over a period of 20 years will be discussed.

There is emerging evidence that how individuals accumulate their physical activity and sedentary behaviour (e.g. bouts, breaks) each day may be important for health. It is possible to assess activity patterns using different objective monitors (e.g. ActiGraph, activPAL, etc), yet there is little consistency in which patterns are examined in children and adults. In this talk, A/Prof Ridgers will discuss her research that is focusing on understanding patterns of activity accumulation. She will describe ways that have been used measure activity patterns, and identify some of the historical and current challenges facing researchers. She will present research that has examined changes in patterns over time and within interventions, and how patterns are associated with health outcomes. She will finish with a discussion that highlights the importance of considering changes in activity across the activity spectrum (from sedentary to vigorous activity). Throughout the presentation, A/Prof Ridgers will highlight opportunities afforded by objective measures to assess activity patterns moving forwards.

A/Prof Nicola Ridgers is a researcher within the Institute for Physical Activity and Nutrition (IPAN) at Deakin University. Her program of research primarily focuses on the measurement of children’s physical activity patterns, examining factors that influence activity levels, and promoting physical activity using theory-based interventions. She currently holds a National Heart Foundation of Australia Future Leader Fellowship that is focusing on the accumulation of activity by youth and associations with cardio-metabolic risk factors.