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SEMINAR: Deconstructing, replicating and engineering instructive niches for stem cell differentiation

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Today's date is Wednesday, August 05, 2020
Deconstructing, replicating and engineering instructive niches for stem cell differentiation : School of Human Sciences Seminar Series Other events...
Abstract: Most cells in our bodies are embedded in a complex matrix of extracellular molecules. These tissue-specific and dynamic microenvironments are essential for the functioning of the cells. But exactly what these microenvironments, or so-called "cell niche", are doing to the cells? Can we capture the "design principles" of these complex matrices on engineered microsystems, and guide in vitro cultured cells to form and function as a tissue? Traditional two-dimensional cell culture systems have been used to investigate the roles of tissue microenviroments. But these experimental systems are often too simplistic to reflect the complexity of the natural microenvironment. On the other hand, native tissue microenvironments, such as those provided by decellularised organs, are too complex to be reverse-engineered into model systems that can be studied and applied. This talk summarises our lab's recent attempts to deconstruct tissue microenvironments into their biochemical and architectural components, and investigate the roles of each components in guiding adult stem cell differentiation. The objective of this seminar is to introduce an interdisciplinary audience to the nature and challenges of our research question, and to present some of the approaches we are using to tackle it. Discussion with the cell biologists, bioengineers, materials scientists after the talk will hopefully bring forth fresh and creative ideas on this project.
Speaker(s) LAM, Yun Wah, Department of Chemistry, City University of Hong Kong
Location Seminar Room 1.81, School of Human Science, Anatomy Building
Contact Christine Page <[email protected]> : 6488 7126
Start Wed, 03 Jul 2019 13:00
End Wed, 03 Jul 2019 14:00
Submitted by Christine Page <[email protected]>
Last Updated Thu, 08 Aug 2019 12:32
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