SEMINAR: Bayliss Seminar series
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Bayliss Seminar series : Ozren Bogdanovic: Don't lose your inheritance: Retention of paternal epigenetic memory in the developing teleost germline |
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Abstract:
Two waves of DNA methylation reprogramming occur during mammalian embryogenesis; during preimplantation development and during primordial germ cell (PGC) formation. However, it is currently unclear how evolutionarily conserved these processes are. Here we characterize the DNA methylomes of zebrafish PGCs at four developmental stages and identify retention of paternal epigenetic memory, in stark contrast to the process in mammals. Gene expression profiling of zebrafish PGCs at the same developmental stages revealed that the embryonic germline is defined by a small number of markers that display strong developmental stage-specificity and that are independent of DNA methylation-mediated regulation. We identified promoters that are specifically targeted by DNA methylation in somatic and germline tissues during vertebrate embryogenesis and that are frequently misregulated in human cancers. Together, these detailed epigenome and transcriptome maps of the zebrafish germline provide novel insights into vertebrate epigenome reprogramming and enhance our understanding of the relationships between germline fate acquisition and oncogenesis.
Speaker(s) |
Ozren Bogdanovic
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Location |
Bayliss Lecture Theatre G33
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Contact |
Academic Services, School of Molecular Sciences
<[email protected]>
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Start |
Fri, 07 Dec 2018 12:00
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End |
Fri, 07 Dec 2018 13:00
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Submitted by |
Academic Services, School of Molecular Sciences <[email protected]>
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Last Updated |
Tue, 04 Dec 2018 11:11
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