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SEMINAR: Bayliss Seminar series

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Today's date is Wednesday, October 21, 2020
Bayliss Seminar series : Ozren Bogdanovic: Don't lose your inheritance: Retention of paternal epigenetic memory in the developing teleost germline Other events...
Abstract: Two waves of DNA methylation reprogramming occur during mammalian embryogenesis; during preimplantation development and during primordial germ cell (PGC) formation. However, it is currently unclear how evolutionarily conserved these processes are. Here we characterize the DNA methylomes of zebrafish PGCs at four developmental stages and identify retention of paternal epigenetic memory, in stark contrast to the process in mammals. Gene expression profiling of zebrafish PGCs at the same developmental stages revealed that the embryonic germline is defined by a small number of markers that display strong developmental stage-specificity and that are independent of DNA methylation-mediated regulation. We identified promoters that are specifically targeted by DNA methylation in somatic and germline tissues during vertebrate embryogenesis and that are frequently misregulated in human cancers. Together, these detailed epigenome and transcriptome maps of the zebrafish germline provide novel insights into vertebrate epigenome reprogramming and enhance our understanding of the relationships between germline fate acquisition and oncogenesis.
Speaker(s) Ozren Bogdanovic
Location Bayliss Lecture Theatre G33
Contact Academic Services, School of Molecular Sciences <[email protected]>
Start Fri, 07 Dec 2018 12:00
End Fri, 07 Dec 2018 13:00
Submitted by Academic Services, School of Molecular Sciences <[email protected]>
Last Updated Tue, 04 Dec 2018 11:11
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