PUBLIC TALK: A Tale of Two Diseases: regulating immune responses in the retina
|A Tale of Two Diseases: regulating immune responses in the retina : The 2018 Ian Constable Lecture
The 2018 Ian Constable Lecture by Professor Andrew Dick, Director, UCL Institute of Ophthalmology.
Our immune system does not operate solely to protect against infection, cancer and tissue damage. The immune system has evolved so that many cells, both of the immune system and non-immune cells in all tissues, have an ability to generate immune responses that regulate and maintain normal cellular, tissue and organ function. Activated and overactive immune responses are observed in many blinding non-infectious disorders. The eye is endowed with an exquisite network of cells capable of regulating function of the ocular tissues compartments (such as the retina and cornea). However, two diseases I will discuss demonstrate how the dysregulation in the immune system generates blinding disease. The first is uveitis, a general and non-specific clinical term to describe inflammation inside the eye and the second is age-related macular degeneration. This talk will describe how our understanding has led to step changes in treatments in children and adults with uveitis and the current research on how the diseases inform our understanding of immune responses that maintain normal tissue function by regulating metabolism and cell function.
Professor Andrew Dick is a clinician scientist and immunobiologist. He is Director of the UCL-Institute of Ophthalmology where he is Duke Elder Professor of Ophthalmology. He is also Chair and Professor of Ophthalmology at the University of Bristol, UK.
The annual Ian Constable Lecture lecture is presented by the Lions Eye Institute and the UWA Institute of Advanced Studies and honours the work of Professor Ian Constable. Professor Constable is recognised as one of the world’s leading ophthalmic surgeons. He was appointed the Lions Foundation Chair of Ophthalmology in 1975. In 1983 Professor Constable established the Lions Eye Institute (LEI) dedicated to the prevention and treatment of blindness and eye disease. Today the LEI is a not-for-profit centre of excellence that combines world class scientific research into the prevention of blindness with the highest level of eye care delivery, combining the expertise of researchers and ophthalmologists.
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