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SEMINAR: Bayliss Seminar Series

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Today's date is Sunday, February 28, 2021
Bayliss Seminar Series : From the discovery of a novel isoprenoid biosynthesis pathway to the design of new antimicrobials Other events...
Today, almost all important microbial infections throughout the world, such as tuberculosis, malaria, nosocomial diseases, are becoming resistant to antibiotics. Antimicrobial multi-drug resistance has been called one of the world's most pressing public health problems. It is therefore urgent to find innovative targets for new antimicrobial drugs. Proteins involved in isoprenoid biosynthesis represent such targets. Isoprenoids are found in all living organisms and are essential for all bacteria. The alternative mevalonate-independent methylerythritol phosphate (MEP) pathway for the biosynthesis of isoprenoids, which is present in many pathogenic bacteria e.g. Mycobacterium tuberculosis, M. leprae, as well as in opportunistic pathogens e.g. enterobacteria, Acinetobacter spp., Pseudomonas spp., and present in the parasitic Plasmodium species responsible for malaria but absent in human represents an attractive target for the design and development of new antimicrobials. We focus on developing novel inhibitors for 1-deoxy-D-xylulose 5-phosphate reductoisomerase (DXR), the second enzyme of the MEP pathway for isoprenoid biosynthesis in pathogens.
Speaker(s) Dr Catherine Grosdemange-Billiard, Université de Strasbourg, France
Location Bayliss Building, G33
Contact The School of Chemistry and Biochemistry Team <[email protected]> : 6488 4402
Start Wed, 21 Sep 2016 13:00
End Wed, 21 Sep 2016 13:45
Submitted by scbevents <admin-[email protected]>
Last Updated Mon, 19 Sep 2016 16:16
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