SEMINAR: Mathematics & Statistics Colloquium
Everyone is warmly invited to our Mathematics and Statistics Colloquium.
Talk title: Design of dose-escalation trials: Research spurred by a trial that went wrong
Talk abstract: In March 2006 the topic of designed experiments briefly hit the
British newspaper headlines when a clinical trial near London went badly
wrong. When a working party of the Royal Statistical Society looked into this,
my experience from designing experiments in other areas, such as agricultural
field trials and microarray experiments, proved useful in improving the design
of dose-escalation trials to obtain better information without compromising
safety or using more volunteers. I shall say something about the
recommendations of the RSS working party, something about the ethical
constraints on Phase I clinical trials, and something about the new designs.
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