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SEMINAR: Assembly of centromeric chromatin in Drosophila and beyond

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Today's date is Thursday, March 28, 2024
Assembly of centromeric chromatin in Drosophila and beyond : School of Anatomy, Physiology & Human Biology Seminar Series Other events...
The Seminar: My lab studies mechanisms involved in epigenetics and epitranscriptomics. Data from our studies of the incorporation of the histone variant CENP-A into centromeric chromatin will be presented. In addition, I will report on our work on the posttranscriptional modification of long noncoding RNAs. Centromeres are the sites where kinetochores are formed and are thus of crucial importance for every dividing cell. The molecular mechanisms governing their assembly, however, are surprisingly divergent in different organisms. Using biochemical and cell biology approaches, we examined the processes and components involved in handling newly synthesized CENP-A prior to chromatin incorporation in Drosophila melanogaster. We found distinct posttranslational modification patterns on CENP-A and uncovered a role for the histone acetyltransferase HAT1 in the processing of pre-loading CENP-A. HAT1 had so far only been implicated in canonical histone assembly, our data now suggest its involvement also in variant histone incorporation.

The Speaker: Dr. Lusser received her Ph.D. in Molecular Biology from the University of Innsbruck, Austria. She carried out postdoctoral research in the area of chromatin remodeling at the University of California, San Diego. She later returned to Innsbruck, where she is now an Associate Professor at the Medical University.
Speaker(s) Alexandra Lusser, Associate Professor, Division of Molecular Biology, Medical University of Innsbruck, Austria
Location Room 1.81, Anatomy building (north), The University of Western Australia
Contact Deborah Hull <[email protected]> : 6488 3313
URL http://www.aphb.uwa.edu.au/research/seminars
Start Mon, 22 Feb 2016 13:00
End Mon, 22 Feb 2016 14:00
Submitted by Deborah Hull <[email protected]>
Last Updated Mon, 08 Feb 2016 17:05
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