UWA Logo What's On at UWA
   UWA HomeProspective Students  | Current Students  | Staff  | Alumni  | Visitors  | About  |     Search UWA    for      
 

EVENT: Raine Lecture

* Login to add events... *
Today's date is Friday, March 29, 2024
Raine Lecture Other events...
Professor Stephen Hill studied Pharmacology in Bristol (BSc, 1976) and then undertook PhD studies in the Department of Pharmacology in Cambridge (PhD 1979). After postdoctoral studies in Cambridge (1979-1981) he was appointed to a lecturer position in the Department of Pharmacy at the University of Nottingham. He joined the Department of Physiology and Pharmacology in 1984 and was subsequently promoted to Reader (1989) and Professor of Molecular Pharmacology (1995). In 1997 he became Director of the Institute of Cell Signalling and then Head of the School of Biomedical Sciences in 2008.

Professor Hill has published over 170 papers. Work in his laboratory, using fluorescent receptor agonists and antagonists, has provided novel insights into regulation by orthosteric and allosteric ligands, as well as receptor dimerization in single living cells. This work has demonstrated negative cooperativity between different ligand-binding conformations. His lab has used fluorescence correlation spectroscopy (FCS) to investigate ligand binding in small 0.2 micrometer squared microdomains of single living cells. FCS studies with a fluorescent agonist have enabled high affinity labeling of the active conformation (R*) of the receptor. Professor Hill’s laboratory has also used a fluorescent antagonist to study the binding characteristics of antagonist-occupied receptor conformations (R) in membrane microdomains of single cells. In addition his lab has developed novel ligand binding assays using cell surface receptors tagged with a novel N terminal luciferase (NanoLuc; Promega) and bioluminescence resonance energy transfer (BRET) to a fluorescent ligand.
Speaker(s) Professor Stephen Hill
Location Bayliss Building - G33 Lecture Theatre
Contact Associate Professor Kevin Pfleger <[email protected]> : 6151 0734
URL http://www.raine.uwa.edu.au/visiting-professors/lectures
Start Mon, 07 Dec 2015 12:00
End Mon, 07 Dec 2015 13:00
Submitted by Amanda Cleaver <[email protected]>
Last Updated Wed, 11 May 2016 10:35
Included in the following Calendars:
Additional Information:
  • Locations of venues on the Crawley and Nedlands campuses are available via the Campus Maps website.
  • Download this event as: Text | iCalendar
  • Mail this event:

Top of Page
© 2001-2010  The University of Western Australia
Questions? Mail [email protected]