Professor Stephen Hill studied Pharmacology in Bristol (BSc, 1976) and then undertook PhD studies in the Department of Pharmacology in Cambridge (PhD 1979). After postdoctoral studies in Cambridge (1979-1981) he was appointed to a lecturer position in the Department of Pharmacy at the University of Nottingham. He joined the Department of Physiology and Pharmacology in 1984 and was subsequently promoted to Reader (1989) and Professor of
Molecular Pharmacology (1995). In 1997 he became Director of the Institute of Cell Signalling and then Head of the School of Biomedical Sciences in 2008.
Professor Hill has published over 170 papers. Work in his laboratory, using fluorescent receptor agonists and antagonists, has provided novel insights into regulation by orthosteric and allosteric ligands, as well as receptor dimerization in single living cells. This work has demonstrated negative cooperativity between different ligand-binding conformations. His lab has used fluorescence correlation spectroscopy (FCS) to investigate ligand binding in small 0.2 micrometer squared microdomains of single living cells. FCS studies with a fluorescent agonist have enabled high affinity labeling of the active conformation (R*) of the receptor. Professor Hill’s laboratory has also used a fluorescent antagonist to study the binding characteristics of antagonist-occupied receptor conformations (R) in membrane microdomains of single cells. In addition his lab has developed novel ligand binding assays using cell surface receptors tagged with a novel N terminal luciferase (NanoLuc; Promega) and bioluminescence resonance energy transfer (BRET) to a fluorescent ligand.
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