SEMINAR: CMCA Seminar: Interactions, Distractions and Attractions: The art of ligand binding studies using NMR spectroscopy

Nuclear Magnetic Resonance (NMR) Spectroscopy may not be the first technique on your list for understanding ligand-target interactions but it is a powerful approach that is capable of monitoring and understanding interactions at the atomic level. This presentation outlines two on-going projects that utilise ligand-observe and protein-observe ligand binding by NMR to support biochemistry, cancer biology and drug discovery. The goal is to demonstrate the power on NMR in providing quantitative data including ligand contact information and measures of affinity from dissociation constants.