SEMINAR: New regulators of physiological adult muscle growth: coordinated actions of muscle stem cells and myofibers
|New regulators of physiological adult muscle growth: coordinated actions of muscle stem cells and myofibers : School of Anatomy, Physiology & Human Biology Seminar Series
The Seminar: Aging is accompanied by a decline in the homeostatic and regenerative capacity of all tissues and organs and it is generally associated with a decline in stem cell function. Muscle aging, in particular, is characterized by the reduction of tissue mass and function, which are particularly prominent in individuals undergoing sarcopenia. The age-associated muscle wasting is also associated with a decline in regenerative ability and a reduction in resident muscle stem cell (satellite cell) number and function. Specifically, our goals are: 1- To gain insight into the mechanisms regulating satellite cell behavior during physiological aging and muscle regeneration. 2- To investigate pathways that may lead to maintenance or loss of muscle mass in the adult. We will discuss our recent findings on both research lines.
The Speaker: Pura Muñoz-Cánoves studied Pharmacology in the University of Valencia. She obtained her PhD in 1990 for work carried out at The Scripps Research Institute, and did postdoctoral work at the University of California-San Diego and The Scripps Research Institute, and in 1994 she joined the Cancer Research Institute in Barcelona as a postdoc, becoming an independent group leader in 1997. In 2002 her group moved to the Centre de Regulació Genòmica in Barcelona, and she became a senior scientist in 2006 in that Institution. In late 2008 she moved to the Pompeu Fabra University after becoming an ICREA Research Professor. At present, she is a Cell Biology and ICREA Professor at the Department of Experimental and Health Sciences at the Pompeu Fabra University.
Her research focuses on the mechanisms regulating skeletal muscle regeneration and growth both in physiological and in pathological conditions. Muscle fiber degeneration and loss of muscle mass occurs in multiple settings, including cancer, cachexia, neuromuscular disorders (Duchenne Muscular Dystrophy –DMD) and during aging, remaining a key factor contributing to morbidity. Understanding the molecular pathways that regulate muscle stem cell-dependent regeneration and gain/loss of muscle mass is therefore crucial for treating muscle wasting-associated disorders, and a major goal of the laboratory.
Pura Muñoz-Cánoves, Experimental and Health Sciences Cell Biology, ICREA and Pompeu Fabra University, Barcelona, Spain
Room 1.81, Anatomy, Physiology & Human Biology Building North
: 6488 3313
Thu, 26 Sep 2013 13:00
Thu, 26 Sep 2013 14:00
Debbie Hull <[email protected]>
Fri, 06 Dec 2013 10:49
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