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SEMINAR: Regulation of mitochondrial gene expression

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Today's date is Tuesday, December 01, 2020
Regulation of mitochondrial gene expression : School of Anatomy, Physiology & Human Biology Seminar Series Other events...
Note change of date: now Wednesday 24 July

The Seminar: Mitochondria play a key role in energy production that is essential for cell health and function. Human mitochondria contain a small and compact genome that is transcribed as long polycistronic transcripts that encompass each strand of the genome, which are processed into mature mRNAs, tRNAs and rRNAs within the mitochondrial matrix. Recently we provided the first comprehensive map of the human mitochondrial transcriptome by near-exhaustive deep sequencing of long and small RNA fractions from purified mitochondria. We have identified previously undescribed transcripts, including small RNA and long non-coding RNAs encoded by the mitochondrial genome. Furthermore despite their common polycistronic origin, we observed wide variation between individual tRNAs, mRNAs, and rRNA amounts, indicating the importance of RNA-binding proteins in the regulation of mitochondrial gene expression. We have investigated the roles of a new class of RNA-binding proteins and found that they are all localized to mitochondria where they regulate mitochondrial gene expression. These RNA-binding proteins have diverse roles in RNA metabolism and protein synthesis that are important for mitochondrial function and cell health.

The Speaker: Aleksandra Filipovska received her PhD in 2002 from the University of Otago, New Zealand. From 2003-2005 she was a NZ Foundation for Research, Science and Technology Fellow at the MRC Mitochondrial Biology Unit in Cambridge, the United Kingdom. In 2006 she relocated to Australia as a NHMRC Howard Florey Fellow and established her research group at the Centre for Medical Research at the University of Western Australia in Perth. She is currently an Australian Research Council Future Fellow at the University of Western Australia and a group leader at the Western Australian Institute for Medical Research. Her research efforts to date have been recognized with the award of several prizes such as the Australian Academy of Sciences Ruth Stephens Gani Medal, ANZSCDB Young Investigator award and the WA Tall Poppy Award. Aleksandra has published in internationally journals such as Cell, Nature Chemical Biology, Journal of Cell Biology and Journal of Biological Chemistry. Her research has been featured on the cover of Cell, Metallomics and Nature Chemical Biology, and it has been highlighted in Nature Biotechnology, Nature Chemical Biology and Cell Cycle. Aleksandra has been invited to present at national (Lorne Genome, Combio, SFRR, AussieMit) and international conferences (Gordon Conference, World Cancer Congress) as well as at institutions in the United States, Europe and Australia. She is an active and contributing member of a number of scientific societies such as ASBMB and ANZSCDB. Her research focuses on the study of mitochondrial gene expression and function in health and disease, and the development of methods for studying and developing therapeutics for inherited mitochondrial diseases.
Speaker(s) Aleksandra Filipovska, Western Australian Institute for Medical Research, UWA
Location Room 1.81, Anatomy, Physiology & Human Biology Building North
Contact Debbie Hull <[email protected]> : 6488 3313
Start Wed, 24 Jul 2013 13:00
End Wed, 24 Jul 2013 14:00
Submitted by Debbie Hull <[email protected]>
Last Updated Tue, 27 Aug 2013 12:01
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