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SEMINAR: Respiratory load-induced cardiorespiratory failure

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Today's date is Monday, March 01, 2021
Respiratory load-induced cardiorespiratory failure : School of Anatomy, Physiology & Human Biology Seminar Series Other events...
The Seminar: Respiratory loads have long been used to stress the respiratory muscles. When these loads cause failure, however, this has been attributed to inadequate pressure generation by the respiratory muscles, especially the diaphragm. Recently, we discovered that in a rat model of load-induced failure, inspiratory drive to the diaphragm was still elevated at the time of failure, indicating that the origin of failure was not central. However, blood pressure decreased and we observed that cardiac troponin, a marker specific for myocardial necrosis, was present. Troponin was released regardless of the type of respiratory load (inspiratory resistive, repeated inspiratory occlusions, and expiratory threshold). Thus, respiratory loads, by causing arterial hypoxemia, reduce O2 delivery to the heart and respiratory muscles. Inadequate O2 delivery, in the face of increased O2 demands, leads therefore to cardiorespiratory, not respiratory, failure. These results may be relevant to acute exacerbations of respiratory diseases, particularly when supplementary O2 is not available.

The Speaker: Prof Iscoe completed his undergraduate and Doctoral studies at McGill University and his post-doc at Albert Einstein College of Medicine. He now holds a cross-appointment with the Department of Biomedical and Molecular Sciences and Department of Medicine at Queen’s University. Prof Iscoe is a respiratory physiologist with a research interests in the control of the diaphragm; skeletal muscle fatigue and injury; cardiorespiratory failure; treatment of carbon monoxide poisoning; and hypercoagulability in obstructive sleep apnoea.
Speaker(s) Professor Steve Iscoe, Physiology and Medicine, Department of Biomedical and Molecular Sciences, Queen’s University, Canada
Location Room 1.81, Anatomy, Physiology & Human Biology Building North
Contact Debbie Hull <[email protected]> : 6488 3313
Start Tue, 27 Nov 2012 13:00
End Tue, 27 Nov 2012 14:00
Submitted by Debbie Hull <[email protected]>
Last Updated Mon, 19 Nov 2012 06:34
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