SEMINAR: �Epigenomics of the dynamic mammalian DNA methylome�

My research focuses on the role of epigenomic modifications in genome organization and transcription in complex eukaryotic organisms. After receiving my Ph.D. from the University of Western Australia, I joined Joseph Ecker's laboratory at The Salk Institute for Biological Studies in 2006. I developed methodologies for utilizing high-throughput DNA sequencing technologies to achieve base-resolution mapping of DNA methylation throughout plant and mammalian genomes. Integration of these reference methylation maps with transcriptome and chromatin modification profiles has yielded new insights into the composition and function of DNA methylation in plants, people, and pluripotency. My ongoing research is focused upon how these complex epigenomic patterns are established and altered, and how they affect the readout of underlying genetic information.