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SEMINAR: Microbiology & Immunology Seminar Series: Characterisation of a successful triple immunotherapy for the treatment of Mesothelioma.

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Today's date is Wednesday, September 23, 2020
Microbiology & Immunology Seminar Series: Characterisation of a successful triple immunotherapy for the treatment of Mesothelioma. : PhD proposal Other events...
Ms Shruti Krishnan will give a talk on "Characterisation of a successful triple immunotherapy for the treatment of Mesothelioma" in the Microbiology & Immunology Seminar room, Friday, 4th May 2012 at 09:25am. Malignant mesothelioma (MM) is a cancer of the pleura and less commonly of the peritoneum, tunica vaginalis and pericardium. One particular obstacle preventing tumour clearance by the immune system is the presence of regulatory T-cells (Tregs). These Tregs are prevalent within murine and human mesotheliomas and their removal results in tumour growth inhibition with the release of anti-tumour effector T cells from immunosuppression. Our work has focused on targeting multiple mechanisms of immune suppression in the AE17 murine model of mesothelioma. Specifically, we targeted the depletion of Tregs, CTLA4 and TGF-beta; using monoclonal antibodies and soluble receptors. We found the triple immunotherapy resulted in tumour clearance in 46% (13/28, from three independent experiments) of the mice treated; with the generation of memory T cells (CD4+CD44+T cells) that prevented tumour re-emergence on rechallenging the cured mice with the original innoculum. Though the triple immunotherapy looks promising with the complete eradication of the established tumours and developing immunological memory; optimization of this approach will likely yield an even better response rate.
Speaker(s) Ms Shruti Krishnan
Location Seminar Room 1.1, 1st Floor L Block, QEII Medical Centre
Contact Gillian Walters <[email protected]> : 9346 2245
Start Fri, 04 May 2012 09:25
End Fri, 04 May 2012 09:45
Submitted by Gillian Walters <[email protected]>
Last Updated Thu, 10 May 2012 10:56
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