SEMINAR: Deep breathing and obstructive lung disease
|Deep breathing and obstructive lung disease : School of Anatomy, Physiology & Human Biology Seminar Series
The Seminar: Deep inspiration (DI) produces a pronounced bronchodilator response in healthy humans but this response is impaired in obstructive lung diseases including both asthma and chronic obstructive pulmonary disease (COPD). How stretch of bronchi causes bronchodilation is still unclear although oscillatory stretch of isolated airway smooth muscle (ASM) reduces force production, suggesting that DI in vivo may directly inhibit ASM contraction. Loss of the response in disease could be due to a fundamental change in the ASM or a change in the loads applied to the muscle. For example reduced airway compliance in disease could impair the response to DI by limiting the stretch of smooth muscle, while loss of parenchymal attachments in COPD may prevent the loads from lung inflation being transmitted to the airway.
The Speaker: Peter completed his PhD in 1997 at the University of Western Australia working on developmental changes in bronchial compliance and airway responsiveness using isolated bronchial segments. After working at Queen’s University in Canada for four years on quantitative bronchoscopy and calcium sensitisation of airway smooth muscle he returned to Perth in 2002 as an academic staff member in the then Department of Physiology. His current research interests focus on the bronchodilator effects of deep inspiration (DI) where by taking a deep breath in causes bronchodilation in healthy people a response that fails or is impaired in both asthma and chronic obstructive pulmonary disease. He has a productive collaboration with clinical colleges at the Queen Elisabeth II Medical Centre allowing him to obtain human lung samples from patients who are undergoing lung resection to treat lung cancer. He is also an associate editor for the Canadian Journal of Physiology and Pharmacology.
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