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SEMINAR: Metabolic regulation of insulin secretion and the impact of exercise

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Today's date is Wednesday, March 03, 2021
Metabolic regulation of insulin secretion and the impact of exercise : School of Anatomy, Physiology and Human Biology Seminar Series Other events...
The Seminar: A large body of work has been produced in the laboratory of Prof. Newsholme detailing the importance of amino acids to insulin secretion. While long-term exposure to high glucose induces oxidative stress in beta cells, conflicting results have been published regarding the impact of ROS on acute glucose exposure and their role in GSIS. Although beta cells are considered to be particularly vulnerable to oxidative damage, as they express relatively low levels of some peroxide-metabolizing enzymes such as catalase and glutathione peroxidase, other less known glutathione-based antioxidant systems are expressed in beta cells at higher levels. Specific interactions between RNS and ROS may be the cause of the vulnerability of pancreatic beta-cells to oxidative damage. While this presentation will provide background information as to the importance of metabolic integration of nutritional and endocrine signals in the beta cell for insulin secretion, the emerging role of amino acid availability for glutathione synthesis and for the maintenance of beta cell function and viability during periods of metabolic disturbance will be described.

The Speaker: Prof. Philip Newsholme was educated at the University of Birmingham and University of Oxford, UK. He then was involved in Postdoctoral training at the Department of Biological Chemistry, University of California, Davis, CA, USA and Department of Clinical Biochemistry, University of Cambridge, UK under the supervision of Prof Donal Walsh and Prof Nick Hales, respectively. Philip Newsholme moved to University College Dublin, Ireland in 1993 to take up a lectureship in Biochemistry and where he set up a research team investigating nutrient, endocrine and immune regulation of insulin secretion and also metabolic adaptions to exercise in healthy and diabetic individuals. This area of research is critical to understanding the pathophysiology of Type-2 diabetes. Philip was promoted to the position of Associate Professor of Metabolic Science in 2007 and was appointed to the Position of Head of Biochemistry in UCD Dublin in September 2008. Philip Newsholme moved to take up the position of Professor and Head of School, Biomedical Sciences, Curtin University, Perth WA, in September 2011. He also collaborates with colleagues in industry via Food for Health Ireland (FHI) and also collaborates with scientists in AstraZeneca (Manchester, UK). Prof. Newsholme is hoping to develop collaborations with companies in Australia, working in the areas of metabolic health and nutrition.
Speaker(s) Professor Philip Newsholme, Head of School, Biomedical Sciences, Faculty of Health Sciencesand Curtin Health Innovation Research Institute, Curtin University
Location Anatomy, Physiology and Human Biology North Wing, 1st floor, Seminar Room (1.81)
Contact Debbie Hull <[email protected]> : 6488 3313
URL https://www.aphb.uwa.edu.au/research/seminars
Start Tue, 06 Mar 2012 13:00
End Tue, 06 Mar 2012 14:00
Submitted by Debbie Hull <[email protected]>
Last Updated Fri, 02 Mar 2012 09:36
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