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SEMINAR: Microbiology & Immunology Seminar Series: Surface properties of urease and persistence of H. pylori

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Today's date is Tuesday, March 02, 2021
Microbiology & Immunology Seminar Series: Surface properties of urease and persistence of H. pylori Other events...
Adj. Assoc. Prof. Mohammed Benghezal will give a talk on surface properties of urease and persistence of H. pylori in the Microbiology & Immunology Discipline Seminar room, Friday, 7 October 2011 at 9:00am. Helicobacter pylori enzyme urease facilitates gastric colonisation by neutralising the acidic pH. A number of in vitro studies have demonstrated urease-dependent activation of monocytes, macrophages and epithelial cells resulting in cytokine and chemokine production and recruitment of inflammatory cells, suggesting an immune modulation role of urease in vitro. A structure-based insertion mutagenesis analysis of the urease complex performed in our laboratory identified a discrete region on the enzyme surface that is needed for persistence of H. pylori in a mouse model of infection. This result confirms a non-enzymatic role of urease in establishing chronic infection. The abundance of urease (10% of the cell weight) and the fact that it is secreted in the extracellular medium support the idea that the surface of the urease interacts directly with host components important for the host-pathogen interaction and immune modulation enabling bacterial persistence.
Speaker(s) Assoc. Prof. Mohammed Benghezal
Location Seminar Room 1.1, 1st Floor L Block, QEII Medical Centre
Contact Olga Eley <[email protected]> : 9346 2245
Start Fri, 07 Oct 2011 09:00
End Fri, 07 Oct 2011 09:45
Submitted by Gillian Walters <[email protected]>
Last Updated Thu, 29 Sep 2011 10:54
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