SEMINAR: �Flt3 inhibitor treatment of myeloproliferative disease in c-Cbl RING finger mutant mice."

Wally Langdon’s research involves studying mice with knockout and knockin mutations in the c-Cbl and Cbl-b genes. Cbl proteins are E3 ubiquitin ligases that target many signalling proteins including antigen receptors and receptor tyrosine kinases. In addition Cbl proteins function as adaptors to enhance signalling responses from these receptors. Cbl mutant mice are used to investigate T cell tolerance, tumour immunity, thymocyte selection and myeloid leukaemia development. A mouse with a knockin mutation in the RING finger domain of c-Cbl develops a myeloid leukaemia and is currently being used as a preclinical model for examining an inhibitor of the receptor tyrosine kinase FLT3.