SEMINAR: �Remodelling Tumour Vasculature: A New Approach to Therapy."

The vasculature of solid tumours displays an aberrant morphology characterized by dilated and fragile vessels, intensive vessel sprouting, and loss of hierarchical architecture. Due to ongoing angiogenesis, immune effector cells generated in vivo, or supplied ex vivo, are often unable to migrate into established tumour parenchyma in sufficient numbers to exert an anti-tumour effect. Ongoing work in Ruth Ganss’s laboratory has established an association between vessel remodelling and an increased anti-tumour immune response. Altering tumour-associated blood vessels and thus enhancing extravasation and function of immune effector cells in the tumour environment is a promising alternative approach to fight cancer. Ruth Ganss is a Research Professor at the Western Australian Institute for Medical Research and NHMRC Senior Research Fellow.