SEMINAR: "The role of notch signaling in colorectal tumorigenesis"

Dr Sylvie Robine’s team investigates the basic mechanisms that regulate cell migration and invasion both in cell cultures and in vivo using mouse models and cancer cell lines. Many pathways have been found to be deregulated in colorectal pathogenesis such as Wnt, Ras, p3 and Notch. They develop conditional mouse models to study the molecular and genetic interactions of these signaling pathways involved in intestinal tumor development. Their goal is to pursue on how Notch and Wnt signals coordinate intestinal epithelial cells homeostasis and what is the molecular basis of their synergistic impact on gut tumorigenesis. Recent results obtained in the group highlight for a role of Notch activation in initiation and progression of colorectal cancers in a p53 deficient background.