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SEMINAR: CMCA Seminar Series

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Today's date is Sunday, October 25, 2020
CMCA Seminar Series : Super-resolution fluorescence microscopy for cell signalling Other events...
We employ single molecule imaging techniques to understand how activation of the T cell receptor on the cell surface leads to an intracellular signalling response. To function in an immune response, T cells become activated when a highly specific pathogen-derived peptide binds to the T cell receptor (TCR). However, the concomitant signaling events are not specific to the TCR raising the question how T cells organise signalling proteins in time and space to control signalling outcomes in health and disease. Our previous data revealed that membrane lipids and proteins co-operate to form stable membrane domains and protein clusters that are necessary for full T cell activation. To understand the underlying principles of the organization of signalling proteins in the T cell membrane, we established a super-resolution microscopy approach based on photo-activation localization microscopy (PALM) and stochastic optical reconstruction microscopy (STORM). These are single molecule imaging techniques that allows us to quantify the number of proteins participating in signalling clusters, the number of clusters and the ratio of proteins within clusters. In other words, we are able to quantify signalling efficiency and thus determine how lipids influence the organization and regulation of signalling processes.
Speaker(s) Professor Katharina Gaus, Centre for Vascular Research, UNSW
Location CMCA Seminar Room, Lvl 1, Physics Bldg The University of Western Australia
Contact CMCA Admin <[email protected]> : 6488 2770
Start Thu, 29 Jul 2010 11:00
End Thu, 29 Jul 2010 12:00
Submitted by CMCA Admin <[email protected]>
Last Updated Wed, 08 Sep 2010 12:40
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