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SEMINAR: The Search for a function of the melanoma tumour antigen melanotransferrin: Iron binding molecule turned pro-tumourigenic signalling protein

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Today's date is Saturday, March 28, 2020
The Search for a function of the melanoma tumour antigen melanotransferrin: Iron binding molecule turned pro-tumourigenic signalling protein : School of Human Sciences Seminar Series Other events...
Melanotransferrin (MTf) is a membrane-bound transferrin homologue that is found in melanoma cells and was one of the first melanoma tumour antigens to be characterized. It possesses an iron-binding site like the iron-binding protein in the blood, transferrin, but does not play a role in normal cellular iron metabolism. This was shown by Richardson through a variety of studies in vitro in cell culture and in vivo using purpose generated melanotransferrin knockout and transgenic mice. However, Richardson later demonstrated that melanotransferrin stimulates melanoma growth, proliferation and migration and more recently appears to play an exciting role in oncogenic signalling via down-regulating the metastasis suppressor protein, NDRG1. Intriguingly, over-expression of NDRG1 can down-regulate MTf. The studies over a period of 20 years will be discussed.
Speaker(s) Des Richardson, Professor of Cancer Cell Bioilogy, Director, Molecular Pharmacology and Pathology Program, University of Sydney
Location Seminar Room 1.81, School of Human Science, Anatomy Building
Contact Christine Page <christine.page@uwa.edu.au> : 7126
URL http://events.uwa.edu.au/view/shs/default
Start Thu, 28 Mar 2019 13:00
End Thu, 28 Mar 2019 14:00
Submitted by Christine Page <christine.page@uwa.edu.au>
Last Updated Tue, 26 Mar 2019 13:10
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