SEMINAR:
  The Search for a function of the melanoma tumour antigen melanotransferrin: Iron binding molecule turned pro-tumourigenic signalling protein
  - School of Human Sciences Seminar Series
		
Thu, 28 Mar 2019 13:00 - Seminar Room 1.81, School of Human Science, Anatomy Building
		
Des Richardson, Professor of Cancer Cell Bioilogy, Director, Molecular Pharmacology and Pathology Program, University of Sydney
Melanotransferrin (MTf) is a membrane-bound transferrin homologue that
is found in melanoma cells and was one of the first melanoma tumour
antigens to be characterized. It possesses an iron-binding site like the
iron-binding protein in the blood, transferrin, but does not play a role
in normal cellular iron metabolism. This was shown by Richardson through
a variety of studies in vitro in cell culture and in vivo using purpose
generated melanotransferrin knockout and transgenic mice. However,
Richardson later demonstrated that melanotransferrin stimulates melanoma
growth, proliferation and migration and more recently appears to play an
exciting role in oncogenic signalling via down-regulating the metastasis
suppressor protein, NDRG1. Intriguingly, over-expression of NDRG1 can
down-regulate MTf. The studies over a period of 20 years will be
discussed.
		
URL: http://events.uwa.edu.au/view/shs/default
		
For more information:
  Christine Page
  christine.page@uwa.edu.au
  7126

Starts       : Thu, 28 Mar 2019 13:00
Ends         : Thu, 28 Mar 2019 14:00
		
Last Updated : Tue, 26 Mar 2019 13:10