SEMINAR: CMCA Seminar: Super-resolution and correlative imaging of malaria parasites
|CMCA Seminar: Super-resolution and correlative imaging of malaria parasites
New microscopy techniques are providing amazing views of the cellular landscape. We have used 3D Structured Illumination Microscopy (SIM), direct Stochastic Optical Reconstruction Microscopy (dSTORM), 3D-Electron Tomography and Block-Face Scanning EM to explore the sub-cellular topography of the malaria parasite, Plasmodium falciparum.
P. falciparum is the most virulent of malaria parasites, causing ~480,000 deaths per year. Efforts to control malaria need to target both asexual multiplication in red blood cells (RBCs), which causes disease, and sexual development, which is responsible for transmission.
We have probed the changes to the host RBC membrane skeleton that mediate rigidity changes and imaged the virulence complex that the parasite establishes at the RBC surface, which mediates adhesion to blood vessel walls. We have explored the changes in the parasite and host cytoskeletal structures that underpin the remarkable reversible morphology changes that permit sexual blood stages to survive in the circulation ready for transfer to the mosquito vector.
Professor Leann Tilley, University of Melbourne
McCusker Auditorium, Harry Perkins Institute of Medical Research
: 6488 5387
Wed, 30 Aug 2017 11:15
Wed, 30 Aug 2017 12:15
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Thu, 20 Jul 2017 12:51
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