SEMINAR: How a hijacked protein became a gateway to studying the evolution of proteins
|How a hijacked protein became a gateway to studying the evolution of proteins : This seminar is part of the Centre for Water Research seminar series.
A few years ago we stumbled upon an interesting peptide biosynthesis in sunflower seeds. A small peptide was buried inside another protein and the peptide emerged from its hiding place by hijacking the protein processing machinery of the 'host' protein. This system has become a lead-in to studying the evolution of proteins.
It recently allowed us to trace the biochemical steps that we think led to the 'birth' or de novo evolution of a protein. With it for example, we can also ask how easily new proteins might be created and how they manage to mimic other proteins. We recently found the processing machinery that was hijacked has evolved a dual functionality. I will discuss the biosynthesis and what it's teaching us, but I promise not to get too detailed!
Assoc. Prof. Mylne (PhD, Botany) worked at the John Innes Centre in the UK (2001-2005), using molecular genetics to study proteins that accelerate flowering in response to prolonged cold (vernalization). In 2006 he moved to the Division of Chemistry & Structural Biology at The Institute for Molecular Bioscience (IMB, UQ) where he held a QEII Fellowship (2008-2012) and was the inaugural John S. Mattick Fellow (2010-2012).
In 2013 he joined the faculty at The University of Western Australia and took up an ARC Future Fellowship in the School of Chemistry & Biochemistry and The ARC Centre of Excellence in Plant Energy Biology. His research interests are protein evolution and the molecular mechanisms underlying the biosynthesis of bioactive peptides.
PS* This seminar is free and open to the public & no RSVP required.
Assoc. Prof. Joshua S. Mylne, ARC Future Fellow School of Chemistry and Biochemistry & ARC Centre of Excellence in Plant Energy Biology | Bayliss Building | The University of Western Australia
Blakers Lecture Room, Ground Floor, Mathematics Building, The University of Western Australia
: 6488 7565
Wed, 11 Jun 2014 16:00
Wed, 11 Jun 2014 17:00
Askale Abebe <firstname.lastname@example.org>
Tue, 10 Feb 2015 16:00
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