SEMINAR: Infrared spectroscopy for clinical chemistry: from laboratory assays to continuous minimal-invasive and non-invasive patient blood glucose monitoring
|Infrared spectroscopy for clinical chemistry: from laboratory assays to continuous minimal-invasive and non-invasive patient blood glucose monitoring
Infrared spectroscopic assays for body fluid analysis are of great interest, because these are reagentless and allow the simultaneous analysis of several analytes. Different measurement techniques have been routinely utilized for blood and derived fluids such as plasma, serum and dialysates. Samples can be fluids or dry-films prepared by water evaporation, and high-throughput applications have been reported recently by us for cancer screening applications.
Continuous measurement technology for patient monitoring has been realized in combination with micro-dialysis. The performance of our infrared spectrometer-based system was tested in several clinical measurement campaigns, using the sensor also in combination with a programmed insulin pump for testing our «artificial pancreas system« for type 1 diabetic subjects and critically ill patients. For safeguarding the spectroscopic multivariate calibration models, the influence of various drugs, when administered in amounts to reach therapeutic concentration levels, has been investigated for glucose cross-sensitivities.
Another promising spectroscopic application is non-invasive blood glucose assay technology based on either near-infrared spectroscopy using the diffuse reflection technique or mid-infrared photoacoustic spectroscopy. An outlook will be given, whether novel photonic technology based on quantum cascade lasers can replace currently favoured electrochemical enzymatic biosensors for continuous metabolite monitoring.
H. Michael Heise
G.33, Bayliss Building
: 6844 4402
Mon, 14 Apr 2014 13:00
Mon, 14 Apr 2014 14:00
Mon, 31 Mar 2014 11:26
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