SEMINAR: Stroke and cerebral ischaemia: exploring potential neuroprotective strategies

The Seminar: We have previously reported that treatment with magnesium following global and focal cerebral ischaemia does not reduce brain damage in normothermic rats (1, 2). However we have shown that mild hypothermia (35°C) combined with magnesium is more effective than either treatment used alone following global and focal ischaemia (3). Treatment is effective when commenced 2 hours post global ischaemia and when commenced 2 or 4, but not 6 hours post-permanent focal ischaemia (4). We are currently further defining therapeutic windows following global ischaemia and transient focal ischaemia.

The Speaker: Bruno Meloni obtained his Bachelor of Science degree at Curtin University in 1985 and his PhD degree at Murdoch University in 1993. In 1996, he started a second Postdoctoral position with the newly formed Stroke Research Group, situated at the ANRI and headed by Clinical Professor Neville Knuckey. A/Prof Meloni was responsible for setting up the molecular biology, in vitro cultivation and animal surgery laboratories and has played a major role in overseeing its direction over the last 15 years. A/Prof Meloni's research has focussed on identifying neuroprotective proteins for the development of potential treatments for ischaemic brain injury and assessing the effectiveness of mild hypothermia and magnesium as a neuroprotective therapy following cerebral ischaemia. To this end, his talk will focus on experimental work performed by the Stroke Research Group over the last several years characterising the efficacy of mild hypothermia and magnesium in stroke and global cerebral ischaemia rat models.