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SEMINAR: Prenatal glucocorticoids, placental development and neurological function

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Today's date is Tuesday, December 10, 2019
Prenatal glucocorticoids, placental development and neurological function : School of Anatomy, Physiology and Human Biology Seminar Series Other events...
The Seminar: Fetal glucocorticoid exposure is a key mechanism proposed to underlie prenatal "programming" of adult cardiometabolic and neuropsychiatric disorders. Regulation of fetal glucocorticoid exposure is achieved by the placental and fetal glucocorticoid "barrier," which involves glucocorticoid inactivation by 11beta-hydroxysteroid dehydrogenase 2 (11beta-HSD2). Mice null for 11beta-HSD2 exhibit altered placental development and function, decreased birth weight, delayed neurodevelopment and increased anxiety and depressive-like behaviour as adults. This raises the question as to whether it is placental or fetal brain 11b-HSD2 that underpins programmed outcomes? Preliminary data suggest that fetal brain 11beta-HSD2 impacts specifically on depressive-like behaviours, but that broader anxiety-related and neurodevelopmental effects are likely to relate to indirect effects of 11-HSD2 in the placenta.

The Speaker: Caitlin completed her PhD at UWA under the supervision of Prof Brendan Waddell and Dr Peter Mark, where she focused on developmental programming and the significance of omega-3 intake in attenuating adverse health outcomes. Caitlin moved to Edinburgh in 2006 to take up a postdoctoral position at The Queen's Medical Research Institute. Here she continued her research interest in developmental programming in the lab of Prof Jonathan Seckl and Prof Megan Holmes. Caitlin then returned to Perth in late 2011 to commence an Assistant Professor position at The School of Anatomy , Phsiology and Human Biology at UWA.
Speaker(s) Assistant Professor Caitlin Wywroll, School of Anatomy, Physiology & Human Biology, UWA
Location Room 1.81, Anatomy, Physiology & Human Biology Building North
Contact Debbie Hull <debbie.hull@uwa.edu.au> : 6488 3313
Start Tue, 07 Aug 2012 13:00
End Tue, 07 Aug 2012 14:00
Submitted by Debbie Hull <debbie.hull@uwa.edu.au>
Last Updated Tue, 31 Jul 2012 07:23
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