SEMINAR: Oxidative stress in tissue: What is it and how do you measure it?

The Seminar:

Oxidative stress is caused by reactive oxygen species (ROS), also known as free radicals, and is evident in many chronic diseases and conditions. Although well recognized as harmful to human health, developing a successful therapy against oxidative stress has proven to be very challenging. I believe this failure is a reflection of our poor understanding of the complex interactions between ROS, tissues and the use of non-specific antioxidants. We are using multiple analytical techniques to improve our understanding of oxidative stress in muscle tissue from a mouse model of muscular dystrophy. I will discuss some of the challenges we are encountering.